The effect of switching from calcineurin inhibitor to sirolimus on the incidence of skin cancers in kidney transplant recipients.
نویسندگان
چکیده
© 2008 The Authors JEADV 2009, 23, 317–368 Journal compilation © 2008 European Academy of Dermatology and Venereology 3 Hsieh MY, Huang PH. The juvenile variant of papular-purpuric ‘gloves and socks’ syndrome and its association with viral infections. Br J Dermatol 2004; 151: 201–206. 4 Feldman R, Harms M, Saurat JH. Papular-purpuric ‘gloves and socks’ syndrome: not only parvovirus B19. Dermatology 1994; 188: 85–87. 5 Aractingi S, Bakhos D, Flageul B et al. Immunohistochemical and virological study of the skin in the papular-purpuric ‘gloves and socks’ syndrome. Br J Dermatol 1996; 135: 599–602.
منابع مشابه
اثر سیرولیموس در کاهش هیپرتروفی بطن چپ در گیرندگان کلیه پیوندی: کارآزمایی بالینی
Background: Persistence of left ventricular hypertrophy (LVH) in renal transplant recipients is associated with unfavorable outcomes. Calcineurin-inhibitor (CNI) nephrotoxicity is a major cause of morbidity and mortality after kidney transplantation. In this study we compared sirolimus (SRL) with calcineurin-inhibitor as primary immunosuppressants for the attenuation of left ventricular hypertr...
متن کاملSirolimus and secondary skin-cancer prevention in kidney transplantation.
BACKGROUND Transplant recipients in whom cutaneous squamous-cell carcinomas develop are at high risk for multiple subsequent skin cancers. Whether sirolimus is useful in the prevention of secondary skin cancer has not been assessed. METHODS In this multicenter trial, we randomly assigned transplant recipients who were taking calcineurin inhibitors and had at least one cutaneous squamous-cell ...
متن کاملSirolimus after kidney transplantation.
The risk of cancer is increased after kidney transplantation and is predominantly attributed to oncogenic immunosuppression. It is a leading cause of death for kidney allograft recipients, and analyses of transplant registry data suggest that mortality related to cancer is on the increase. Strategies to reduce the risk of cancer bymodifying immunosuppression are therefore desirable but must be ...
متن کاملSirolimus Increases T-Cell Abundance in the Sun Exposed Skin of Kidney Transplant Recipients
BACKGROUND Kidney transplant recipients (KTRs) receiving the mammalian target of rapamycin inhibitor sirolimus may display a reduced risk of skin cancer development compared to KTRs receiving calcineurin inhibitors. Despite studies investigating the effects of these 2 drug classes on T cells in patient blood, the effect these drugs may have in patient skin is not yet known. METHODS Fifteen pa...
متن کاملSirolimus effects on cancer incidence after kidney transplantation: a meta-analysis
Sirolimus, an immunosuppressant option for kidney transplant recipients, may reduce cancer risk by interrupting the mammalian target of rapamycin pathway. However, studies of sirolimus and cancer incidence in kidney recipients have not been definitive, and have had limited ability to examine specific cancer types. The literature was systematically reviewed to identify randomized controlled tria...
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ورودعنوان ژورنال:
- Journal of the European Academy of Dermatology and Venereology : JEADV
دوره 23 3 شماره
صفحات -
تاریخ انتشار 2009